True World Intelligence News (TWIN)

Voice of Truth: Proclaimer of truth and defender of the faithful

Flashback 2002: cancer-causing monkey virus contaminates polio vaccine

with one comment

English: Micrograph of Hodgkin lymphoma, abbre...

English: Micrograph of Hodgkin lymphoma, abbreviated HL. Lymph node FNA specimen. Field stain. The micrograph shows a mixture of cells common in HL: Eosinophils. Reed-Sternberg cells. Plasma cells. Histocytes. See also Image:Hodgkin lymphoma cytology small.jpg (Photo credit: Wikipedia)

BACKGROUND:

Non-Hodgkin lymphoma has increased in frequency over the past 30 years, and is a common cancer in HIV-1-infected patients. Although no definite risk factors have emerged, a viral cause has been postulated. Polyomaviruses are known to infect human beings and to induce tumours in laboratory animals. We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma.

METHODS:

We analysed systemic non-Hodgkin lymphoma from 76 HIV-1-infected and 78 HIV-1-uninfected patients, and non-malignant lymphoid samples from 79 HIV-1-positive and 107 HIV-1-negative patients without tumours; 54 colon and breast carcinoma samples served as cancer controls. We used PCR followed by Southern blot hybridisation and DNA sequence analysis to detect DNAs of polyomaviruses and herpesviruses.

FINDINGS:

Polyomavirus T antigen sequences, all of which were SV40-specific, were detected in 64 (42%) of 154 non-Hodgkin lymphomas, none of 186 non-malignant lymphoid samples, and none of 54 control cancers. This difference was similar for HIV-1-infected patients and HIV-1-uninfected patients alike. Few tumours were positive for both SV40 and Epstein-Barr virus. Human herpesvirus type 8 was not detected. SV40 sequences were found most frequently in diffuse large B-cell and follicular-type lymphomas.

INTERPRETATION:

SV40 is significantly associated with some types of non-Hodgkin lymphoma. These results add lymphomas to the types of human cancers associated with SV40.

 

http://www.ncbi.nlm.nih.gov/pubmed/11897278

Advertisements

Written by voiceoftruthusa

October 14, 2013 at 5:05 am

Posted in Uncategorized

One Response

Subscribe to comments with RSS.

  1. […] Flashback 2002: cancer-causing monkey virus contaminates polio vaccine (voiceoftruthusa.wordpress.com) […]


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: